Kidney Cancer

Age, Chronic kidney disease, Exposure to cadmium and other chemicals, Family history of kidney cancer, Gender, Genetic conditions, High blood pressure, Long-term dialysis, Obesity, Overuse of certain medications, Race, Smoking

Age — Kidney cancer is typically found in adults and is usually diagnosed between the ages of 50 and 70.

Chronic kidney disease — People who have decreased kidney function but don’t yet need dialysis may be at higher risk for the development of kidney cancer.

Exposure to cadmium and other chemicals — Some studies have shown a connection between exposure to the metallic element cadmium and kidney cancer. Working with batteries, paints, or welding materials may increase a person’s risk as well. This risk is even higher for smokers who have been exposed to cadmium. Workplace exposure to other chemicals (such as some herbicides) and organic solvents (particularly trichloroethylene) has been linked to an increased risk of RCC.

Family history of kidney cancer — People who have first-degree relatives (parents, siblings, or children) with kidney cancer have an increased risk of developing the disease. This risk increases if a number of extended family members have been diagnosed with kidney cancer, including grandparents, aunts, uncles, nieces, nephews, grandchildren, and cousins, and if these family members were diagnosed before the age of 50, had cancer in both kidneys, and/or had more than one tumor in the same kidney.

Gender — Men are two to three times more likely to develop kidney cancer than women.

Genetic conditions — Although kidney cancer can run in families, inherited kidney cancers occur only about 5 percent of the time. People who have the following conditions have a higher risk of getting kidney cancer: Von Hippel-Lindau syndrome (VHL), hereditary non-VHL clear cell renal cell carcinoma, hereditary papillary renal cell carcinoma (HPRCC), Birt-Hogg-Dubé syndrome (BHD), hereditary leiomyomatosis and renal cell carcinoma (HLRCC), tuberous sclerosis complex (TSC), familial renal cancer, Cowden syndrome, and hereditary renal oncocytoma.

High blood pressure — Kidney cancer risk increases in people with high blood pressure. Some studies have suggested that certain medicines used to treat high blood pressure may raise the risk of kidney cancer, but it is hard to tell whether this increased risk is due to the condition, the medicine used to treat it, or both.

Long-term dialysis — People who have been on dialysis for a long time may develop cancerous cysts in their kidneys. These growths are usually found early and can often be removed before the cancer spreads.

Obesity — People who are very overweight have a higher risk of developing RCC, possibly due to hormone changes from obesity.

Overuse of certain medications — Painkillers containing phenacetin have been banned in the United States since 1983 because of their link to transitional cell carcinoma. Diuretics and analgesic pain pills, such as aspirin, acetaminophen, and ibuprofen, have also been linked to kidney cancer.

Race — African Americans and Native Americans/Alaska Natives have slightly higher rates of RCC than do whites.

Smoking — Smoking tobacco doubles the risk of developing kidney cancer. It is believed to cause about 30% of kidney cancers in men and about 25% in women. The risk drops if you stop smoking, but it takes many years to get to the risk level of someone who never smoked.

Blood in the urine

Pain or pressure in the side or back

A mass or lump in the side or back

Swelling of the ankles and legs

High blood pressure

Anemia (low red blood cell counts)

Fatigue (tiredness)

Loss of appetite

Unexplained weight loss

Fever that keeps coming back and is not from a cold, flu, or other infection.

For men, a rapid development of a cluster of enlarged veins known as a varicocele, around a testicle, particularly the right testicle, may indicate that a large kidney tumor may be present.

External-beam radiation therapy (EBRT) is the type of radiation therapy used most often for kidney cancer. Radiation is very rarely used alone to treat kidney cancer because of the damage it causes to the healthy kidney.

Radiation may be used only if a patient cannot have surgery and, even then, usually only on areas where the cancer has spread and not on the primary kidney tumor.

Radiation may be used as palliative therapy to help ease symptoms, such as pain, bleeding, or problems caused by the spread of cancer (especially to the bones or brain).